阮敏

   阮敏，男，中共党员，博士，主任医师，现任上海交通大学医学院附属第九人民医院口腔颌面-头颈肿瘤科行政副主任，口腔颌面-头颈肿瘤教研室副主任，美国纽约Memorial Sloan-Kettering Cancer Center和德州MD-Anderson Cancer Center访问学者，中国抗癌协会头颈肿瘤专委会委员，世界华人肿瘤医师协会委员，上海市口腔医学会口腔颌面-头颈肿瘤专委会委员，上海市医学会显微外科专委会青年委员，教育部学位中心评审专家，上海市科技奖励评审专家。

   长期致力于口腔颌面肿瘤的基础与临床研究，从事口腔颌面-头颈肿瘤的外科治疗工作近18年，带领团队累计完成口腔颌面肿瘤全麻手术近6000台，其中III-IV级手术2000余台，修复重建手术1000余台。依托国家口腔医学中心和国家口腔疾病临床医学中心，聚焦口腔鳞癌和腺样囊性癌，以第一或通讯作者发表论文33篇，SCI收录24篇，主编专著2部（《口腔颌面显微外科的基本理论与操作教程》，《旋髂浅动脉穿支皮瓣---口腔颌面部应用》），参编专著2部，获实用新型专利3项，以第一负责人主持国家自然科学基金4项，上海市自然科学基金1项，其他各类基金6项。曾获全国优博提名、上海市优博、上海市“浦江人才”，上海市“医苑新星”杰出青年医学人才，上海市教委优秀青年骨干教师、上海交通大学“晨星学者”、上海交通大学医学院“新百人计划”、上海交通大学医学院“上药杏林育才奖”、上海九院“十佳教师”、上海九院优秀进修生带教老师。

【代表性科研项目】

1. 国家自然科学基金面上项目，82072983，2021.1.1-2024.12.31  口腔鳞癌细胞趋化pDC促进淋巴结转移前微环境形成的分子机制研究 55万，在研，主持

2. 国家自然科学基金面上项目，81772870，2018.1.1-2021.12.31  TLR-9介导口腔粘膜癌变细胞抑制pDC免疫监控功能的分子机制研究 45万，在研，主持

3. 上海市卫计委资助课题，201740186，2018.1.1-2020.12.31  口腔癌变细胞TLR-9过表达与肿瘤浸润pDC细胞免疫功能下调的相关性研究，结题，主持

4. 国家自然科学基金面上项目，81472517，2015.1.1-2018.12.31  口腔粘膜上皮癌变过程中TLR-9基因过表达的转录调控机制研究 72万，结题，主持

5. 国家自然科学基金青年项目，81104029，2012.1.1-2014.12.31  TLR-9活化AP-1促进口腔粘膜上皮癌变的分子机制研究 23万，结题，主持

【代表性论文】

1. Han N, Li X, Wang Y, Wang L, Zhang C, Zhang Z*, Ruan M*, Zhang C. Increased tumor-infiltrating plasmacytoid dendritic cells promote cancer cell proliferation and invasion via TNF-α/NF-κB/CXCR-4 pathway in oral squamous cell carcinoma. J Cancer. 2021 Mar 19;12(10):3045-3056.

2. Wang Y, Wang L, Li X, Qu X, Han N*, Ruan M*, Zhang C. Decreased CSTA expression promotes lymphatic metastasis and predicts poor survival in oral squamous cell carcinoma. Arch Oral Biol. 2021 Mar 31;126:105116.

3. Han J, Han N, Xu Z, Zhang C, Liu J*, Ruan M*. Expression profile of circular RNA and construction of circular RNA-Micro RNA network in salivary adenoid cystic carcinoma. Cancer Cell Int. 2021 Jan 7;21(1):28.

4. Wang L, Wang Y, Han N, Wang X*, Ruan M*. HPRT promotes proliferation and metastasis in head and neck squamous cell carcinoma through direct interaction with STAT3. Exp Cell Res. 2021 Feb 1;399(1):112424.

5. Yang W, Jiang C, Xia W, Ju H, Jin S, Liu S, Zhang L, Ren G, Ma H*, Ruan M*, Hu J*. Blocking autophagy flux promotes interferon-alpha-mediated apoptosis in head and neck squamous cell carcinoma. Cancer Lett. 2019 Jun 1;451:34-47.

6. Ju H, Mao L, Zhang L, Liu S, Wu Y, Ruan M*, Hu J*, Ren G*. Ultrasound hyperthermia enhances chemo-sensitivity in oral squamous cell carcinoma by TRIF-mediated pathway. J Oral Pathol Med. 2018 Nov;47(10):964-971. IF=2.237

7. Ju H, Zhang L, Mao L, Liu S, Xia W, Hu J*, Ruan M*, Ren G*. Altered expression pattern of circular RNAs in metastatic oral mucosal melanoma. Am J Cancer Res. 2018 Sep 1;8(9):1788-1800.IF=3.998

8. Han N, Lu H, Zhang Z*, Ruan M*, Yang W, Zhang C. Comprehensive and in-depth analysis of microRNA and mRNA expression profile in salivary adenoid cystic carcinoma. Gene. 2018 Dec 15;678:349-360.

9. 韩楠男，刘胜文，阮敏*，杨雯君，孙坚，张陈平. 腺体保存术在下颌下腺良性肿瘤治疗中的应用，口腔医学 2017 ,37 (2 ):126-130.

10. 张煦，许恩馨，阮敏*. Toll样受体9与头颈部鳞状细胞癌关系的研究进展，国际口腔医学杂志 2017，44（5）：596-601.

11. Ju H, Zhang L, Mao L, Wu Y, Liu S, Ruan M*, Hu J*, Ren G*. A comprehensive genome-wide analysis of the long noncoding RNA expression profile in metastatic lymph nodes of oral mucosal melanoma. Gene. 2018 Oct 30;675:44-53.  pii: S0378-1119(18)30720-0. doi: 10.1016/j.gene.2018.06.064.

12. Han N, Zhang Z, Jv H, Hu J*, Min Ruan*, Zhang C. Culture supernatants of oral cancer cells induce impaired IFN-α production of pDCs partly through the down-regulation of TLR-9 expression. Arch Oral Biol. 2018 Jun 5;93:141-148.

13. Nannan Han, Zun Zhang, Shengwen Liu, Andrew Ow*, Min Ruan*, Wenjun Yang, Chenping Zhang. Increased Tumor-Infiltrating Plasmacytoid Dendritic Cells Predicts Poor Prognosis in Oral Squamous Cell Carcinoma，Archives of Oral Biology 2017 Jun;78:129-134.

DOI：doi.org/10.1016/j.archoralbio.2017.02.012.

14. Nannan Han, Huishan Ong, Zhihui Liu*, Min Ruan*,Wenjun Yang, Chenping Zhang，Lymph node involvement predicts poor prognosis in primary tongue adenoid cystic carcinoma: A preliminary study of 54 cases，Journal of Cranio-Maxillo-Facial Surgery 2017, 45(4):589-594. DOI：doi.org/10.1016/j.jcms.2017.01.012.

15. 黄擎，韩楠男，刘胜文，王丽珍，阮敏*，杨雯君，张陈平，唾液腺腺样囊性癌颈淋巴结转移规律的临床研究，中国肿瘤临床，2016.12.30，（24）：1094~1098

16. Liu, S, Ow, A, *Ruan, M, Yang, W, Zhang, C, Wang, L, Zhang, C， Prognostic factors in primary salivary gland mucoepidermoid carcinoma: an analysis of 376 cases in an Eastern Chinese population，International Journal of Oral and Maxillofacial Surgery，2014.6.01，43（6）：667~673.

17. Li Siyi，Liu Shengwen，Ruan Min(*)，Yang Wenjun，Wang Lizheng，Zhang Chenping，Increased expression of MUC-1 has close relation with patient survivor in high-grade salivary gland mucoepidermoid carcinoma，Journal of Oral Pathology & Medicine，2014.9.01，43（8）：579~584.

18. Liu, Shengwen, Ruan, Min*, Li, Siyi，Wang, Lizheng，Yang, Wenjun，Increased expression of MUC1 predicts poor survival in salivary gland mucoepidermoid carcinoma.，J Craniomaxillofac Surg，2014.12.01，42（8）：1891~1896.

19. *Ruan, Min; Thorn, Katherine; Liu, Shengwen; Li, Siyi; Yang, Wenjun; Zhang, Chunye; Zhang, Chenping，The secretion of IL-6 by CpG-ODN-treated cancer cells promotes T-cell immune responses partly through the TLR-9/AP-1 pathway in oral squamous cell carcinoma，International Journal of Oncology，2014.6.01，44（6）：2103~2110

20. *Ruan, Min; Zhang, Zun; Li, Siyi; Yan, Min; Liu, Shengwen; Yang, Wenjun; Wang, Lizheng; Zhang, Chenping，Activation of Toll-Like Receptor-9 Promotes Cellular Migration via Up-Regulating MMP-2 Expression in Oral Squamous Cell Carcinoma，PLos One，2014.3.21，9（3）:e92748

21. * Ruan, Min，Toll-like receptor-9 agonists increase cyclin D1 expression partly through activation of activator protein-1 in human oral squamous cell carcinoma cells.，Cancer Science，2012.09.14，103（11）：1938~1945

22. Ruan Min; Zhang Zun; Li Siyi; Yang Wenjun; Wang Lizheng; *Zhang Chenping，Increased expression of Toll-like receptor-9 has close relation with tumour cell proliferation in oral squamous cell carcinoma，Archives of Oral Biology，2011.9.01，56（9）：877~884

23. Ruan, M.，Ji, T.，Wu, Z.，Zhou, J.，Zhang, C.，Evaluation of expression of midkine in oral squamous cell carcinoma and its correlation with tumour angiogenesis，International Journal of Oral and Maxillofacial Surgery，2007.2.01，36（2）：159~164

24. Ruan Min; Ji Tong; Yang Wenjun; Duan Wenhu; Zhou Xiaojian; He Jiacai; Zhou Jian; Chen Wantao; Zhang Chenping，Growth inhibition and induction of apoptosis in human oral squamous cell carcinoma Tca-8113 cell lines by Shikonin was partly through the inactivation of NF-kappa B pathway，Phytotherapy Research，2008.3.01，22（3）：407~415

25. Ruan Min; Zhang Zun; Wang Lizheng; Dong Minjun; Liu Shengwen; *Yang Wenjun; Zhang Chenping，Oral and maxillofacial desmoid-type fibromatoses in an eastern Chinese population: a report of 20 cases，Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology，2011.3.01，111（3）：340~345

26. Ruan Min; Zhang Zun; *Li Siyi; Yang Wenjun; Sun Jian; Zhang Chenping，Gland-preserving surgery can effectively preserve gland function without increased recurrence in treatment of benign submandibular gland tumour，British Journal of Oral and Maxillofacial Surgery，2013.10.01，51（7）：615~619

27. Min, R.; Zun, Z.; Min, Y.; Wenhu, D.; Wenjun, Y.; *Chenping, Z.，Shikonin inhibits tumor invasion via down-regulation of NF-kappa B-mediated MMP-9 expression in human ACC-M cells，Oral Diseases，2011.5.01，17（4）：362~369

28. Min, R.; Siyi, L.; *Wenjun, Y.; Ow, A.; Lizheng, W.; Minjun, D.; Chenping, Z.，Salivary gland adenoid cystic carcinoma with cervical lymph node metastasis: a preliminary study of 62 cases，International Journal of Oral and Maxillofacial Surgery，2012.8.01，41（8）：952~957

29. *Zhang Chenping; Ruan Min#; Xu Liqun; Hu Yongjie; Yang Wenjun; Ji Tong; Qv Xingzhou; Li Siyi; Ow, Andrew; Ma Jizhuang; Wu Yiqun，Dental Implant Distractor Combined With Free Fibular Flap: A New Design for Simultaneous Functional Mandibular Reconstruction，Journal of Oral and Maxillofacial Surgery，2012.11.01，70（11）：2687~2700