张亨国

个人信息

张亨国，口腔医学博士，副教授，主治医师，硕士研究生导师，安徽医科大学高层次引进人才（四类），合肥市D类高层次人才，四川大学口腔疾病防治全国重点实验室访问学者，安徽省医师协会口腔医师分会青年委员，安徽省口腔种植专委会委员。研究方向包括：1）干细胞谱系命运与骨衰老及再生修复；2）口腔微生物与全身系统性疾病；3）颌骨衰老与缺损高危因素筛选。近三年以第一/通讯作者（含共同）在Cell Death & Differentiation、International Journal of Oral Science、iMeta、Stem Cell Research & Therapy、Journal of Gerontology: Biological Sciences等期刊发表SCI论文十余篇。主持国家自然科学基金青年项目、国家重点实验室开放课题、安徽省优秀青年教师培育项目等五项。主持校级教学改革课题两项，参编《口腔种植临床解剖学》。获安徽医科大学復元科技新星、中华口腔医学会青年科学家报告会三等奖、iMeta期刊杰出执行副主编、南京医科大学优秀博士学位论文。在第100届国际牙科协会（IADR）学术年会、2024年IADR中国分会杰出青年学者报告会作Presentation。担任iMeta执行副主编、Advanced Genetics副编委、Phenomics责任编辑、南京医科大学学报客座编辑、hLife青年编委等。

工作邮箱：zhanghengguo@ahmu.edu.cn

近三年发表学术论文

1)Zifei Wang, …, Hengguo Zhang*. NEAT1 regulates BMSCs aging through disruption of FGF2 nuclear transport. Stem cell research & therapy. 2025, 10.1186/s13287-025-04156-1. (Stem cell, JCR Q1, Top, IF:7.1)

2)Wenyu Zhen, …, Hengguo Zhang*. Cardiovascular disease therapeutics via engineered oral microbiota: Applications and perspective. iMeta. 2024, 10.1002/imt2.197. (Microbiology, JCR Q1, Top, IF:23.8)

3)Zifei Wang, …, Hengguo Zhang*. Promising dawn in tumor microenvironment therapy: engineering oral bacteria. International Journal of Oral Science. 2024, 10.1038/s41368-024-00282-3. (Dentistry, JCR Q1, Top, IF:14.9)

4)Qing Wang, …, Hengguo Zhang*. Occlusion dysfunction and Alzheimer's disease: Mendelian randomization study. Frontiers in Aging Neuroscience. 2024, 10.3389/fnagi.2024.1423322. (Aging, JCR Q1, IF: 4.1)

5)Zifei Wang, …, Hengguo Zhang*. Deciphering the Biological Aging Impact on Alveolar Bone Loss: Insights From α-Klotho and Renal Function Dynamics. Journal of Gerontology: Biological Sciences. 2024, 10.1093/gerona/glae172. (Aging, JCR Q1, Top, IF: 4.3)

6)Yihan Chen, …, Hengguo Zhang*, Jianguang Xu. Modifying MSCs-derived EVs with esterase-responsive and charge-reversal cationic polymers enhances bone regeneration. iScience. 2024, 10.1016/j.isci.2024.110801. (Multidisciplinary, JCR Q1, IF: 4.6)

7)Sensen Yu, …, Hengguo Zhang*, Yuanyin Wang*, Xiaoyu Sun*, Xin He*. Artificial Intelligence Diagnosing of Oral Lichen Planus: A Comparative Study. Bioengineering-Basel. 2024, 10.3390/bioengineering11111159. (JCR Q2, IF: 3.8)

8)Wansu Sun, …, Hengguo Zhang*, Liling Hong*. The relationship between fixed dental prostheses, blood lead levels, and liver function: Mediating effects and gender differences. Environmental pollution, 2024, 10.1016/j.envpol.2024.125268. (JCR Q1, Top, IF: 7.6)

9)Xiaoyun Liu, …, Hengguo Zhang*. Associations between vitamin D levels and periodontal attachment loss. Clinical Oral Investigation. 2023, 10.1007/s00784-023-05100-4. (Dentistry, JCR Q1, IF:3.606)

10)Zhang Hengguo, ..., Jiang Hongbing*. LncRNA NEAT1 controls the lineage fates of BMSCs during skeletal aging by impairing mitochondrial function and pluripotency maintenance. Cell Death & Differentiation. 2022, 10.1038/s41418-021-00858-0. (Molecular/Cell Biology, JCR Q1, Top, IF:12.4)