张亨国

张亨国，2021年至今,于安徽医科大学先后任讲师、副教授，口腔疾病防治全国重点实验室访问学者（导师：袁泉教授），合肥市D类高层次人才（市级领军人才），口腔医学博士（导师：江宏兵教授），主治医师，硕士研究生导师，安徽省口腔医学会口腔种植专委会委员，安徽省医师协会口腔医师分会青年委员。研究方向包括：1）干细胞谱系命运与骨衰老及再生修复；2）口腔微生物与全身系统性疾病；3）颌骨衰老与缺损高危因素筛选。近两年以第一/通讯作者在Cell Death & Differentiation、International Journal of Oral Science、Clinical Oral Investigation等国际期刊发表学术论文8篇。主持国家自然科学基金、江苏省教育厅基金、安徽医科大学高层次人才引进基金等四项。获南京医科大学优秀博士学位论文（2022）、中华口腔医学会青年科学家（2023）、iMeta期刊杰出执行副主编（2023）、TMR期刊优秀青年编委（2023）。担任iMeta执行副主编，iLiver科学编辑，以及hLife、Journal of Biomedical Research、Medicine Advances、TMR、口腔疾病防治等十余本期刊青年编委/客座编辑，担任iMeta、The Innovation Medicine、Aging、FASEB J、Heliyon等二十余本期刊特约审稿人/审稿专家。

工作邮箱：zhanghengguo@ahmu.edu.cn

科研方向

主要致力于间充质干细胞谱系命运与骨再生修复的分子机制研究。包括：基于颌骨修复及间充质干细胞模型的单细胞组学及三维基因组学筛选转录及表观遗传靶标，重点围绕衰老干细胞线粒体功能损伤、多潜能稳态失衡、细胞周期蛋白异常转运、核仁蛋白相分离等方向，深入探索干细胞衰老、耗竭及其对器官或组织再生的影响。

近五年发表学术论文

1) Zhang Hengguo, ..., Jiang Hongbing*. LncRNA NEAT1 controls the lineage fates of BMSCs during skeletal aging by impairing mitochondrial function and pluripotency maintenance. Cell Death Differ.2022, 10.1038/s41418-021-00858-0. (IF:12.4) (中科院一区Top)

2) Wang, Zifei., …,Zhang Hengguo*. Promising dawn in tumor microenvironment therapy: engineering oral bacteria. International Journal of Oral Science.2024, 10.1038/s41368-024-00282-3.(IF:14.9) (中科院一区Top)

3) Yali Wang, …,Hengguo Zhang*, Jianguang Xu*. Automated localization of mandibular landmarks in the construction of mandibular median sagittal plane. European Journal of Medical Research.2024, 10.1186/s40001-024-01681-2. (IF: 4.2) (中科院三区)

4) Menglin Hu, …,Hengguo Zhang*, Yuanyin Wang*. Data on hematological parameters and generalized severe periodontitis in the United States. Data Brief.2024, 10.1016/j.dib.2023.110010. (IF:1.2) (JCR Q2)

5) Li QR, Lin LT, Zhang C, Hengguo Zhang, Ma Y, Qian Haisheng*, Chen Xu-Lin*, Wang Xianwen*.Journal of nanobiotechnology,2024,10.1186/s12951-023-02246-x. (IF:10.2) (中科院一区)

6) Wansu Sun, …,Hengguo Zhang*.The risk of dental restoration-related lead exposure on renal function. Chemosphere. 2023, 10.1016/j.chemosphere.2023.139405. (IF: 8.8) (中科院二区)

7) Xiaoyun Liu, …,Hengguo Zhang*.Associations between vitamin D levels and periodontal attachment loss. Clinical Oral Investigation.2023, 10.1007/s00784-023-05100-4. (IF:3.4) (中科院二区)

8) Wenhao Zhang, …,Hengguo Zhang*.The indicative role of inflammatory index in the progression of periodontal attachment loss. European Journal of Medical Research.2023, 10.1186/s40001-023-01247-8. (IF: 4.2) (中科院三区)

9) Yuanyuan Chuai, …,Hengguo Zhang*.Association of vitamin K, fibre intake and progression of periodontal attachment loss in American adults. BMC Oral Health.2023, 10.1186/s12903-023-02929-9. (IF:2.9) (JCR2区)

10) Xu Rongyao, Xie HY, Shen X, HuangJD,Zhang Hengguo, …, Jiang Hongbing*. Impaired Efferocytosis Enables Apoptotic Osteoblasts to Escape Osteoimmune Surveillance During Aging. Adv Sci (Weinh).2023, doi: 10.1002/advs.202303946（IF=15.1) (中科院一区Top)

11)Zhang Hengguo, …, Jiang Hongbing*. Trabeculae microstructure parameters serve as effective predictors for marginal bone loss of dental implant in the mandible. Sci Rep.2020, 10.1038/s41598-020-75563-y.（IF=4.6) (中科院三区)

12) Xu Rongyao, Shen Xin, Xie Hanyu,Zhang Hengguo, …, Jiang Hongbing*. Identification of the canonical and noncanonical role of miR-143/145 in estrogen-deficient bone loss. Theranostics.2021, 10.7150/thno.55041.（IF=12.4) (中科院一区Top)