发布时间:2025-03-26 来源:
许瑞,男,1993年06月生,安徽全椒人,中共党员,医师,口腔颌面外科学博士,安徽医科大学校聘副教授,硕士研究生导师。2015年取得安徽医科大学口腔医学学士学位,2019年取得安徽医科大学口腔临床医学硕士学位(导师:邹多宏教授),2023年取得武汉大学医学博士学位(导师:陈刚教授)。主要研究方向为:纳米技术在口腔鳞癌诊治及软硬组织修复中的应用。主持省厅级、校级科研课题3项,以第一/通讯作者(含共同)在《Biomaterials》、《Analytical Chemistry》、《Advanced Healthcare Materials》、《Chemical Engineering Journal》、《ACS Applied Materials & Interfaces》等国际期刊上发表SCI论文12篇。
科研方向
1.细胞外囊泡介导口腔鳞癌免疫逃逸机制
2.基于纳米技术的细胞外囊泡活性递送系统用于口腔鳞癌诊治
3.功能化细胞外囊泡用于口腔软硬组织修复
科研项目
1.2023年安徽医科大学基础与临床合作研究提升计划资助项目,2023xkjT046,弓形虫外泌体疫苗联合PD-1单抗提高肿瘤免疫治疗疗效的研究,2024/1-2026/12,20万,主持,在研。
2.2023年安徽省转化医学研究院科研基金培育项目,2023zhyx-C90,基于弓形虫外泌体的靶向药物递送载体构建及其在口腔鳞癌免疫治疗中的应用,2024/1-2026/12,8万,主持,在研。
3.安徽医科大学2023年4类人才引进科研启动经费项目,40万,主持,在研。
代表性论文(#第一作者、*通讯作者)
1.Xu R#, Xu Z-W#, Si Y-C, et al., Wu Z-Y*, Zhang G-L* (2020). Oxygen vacancy defect-induced activity enhancement of Gd doping magnetic nanocluster for oxygen supplying cancer theranostics. ACS Appl. Mater. Interfaces. 12(33): 36917–36927. (IF=9.229,中科院二区Top)
2.Xu R#, Yu Z-L#, Liu X-C, et al., Wu M*, Chen G* (2023). Aptamer-assisted traceless isolation of PD-L1-positive small extracellular vesicles for dissecting their subpopulation signature and function. Anal. Chem. 95(2): 1016–1026. (IF=6.7,中科院一区Top)
3.Xu R#, Zhao Z-Y#, Zhou L-X#, et al., Cao Y*, Pan Z*, Zou D-H* (2024). GelMA-based moldable osteogenic paste inspired by ceramic craft for alveolar bone regeneration. Int. J. Biol. Macromol. 283: 137058. (IF=7.7,中科院一区Top)
4.Wang S-M#, Wang D#, Shen Y-Q, et al., Jia F*, Zheng X-Y*, Wen H-Q*, Xu R* (2025). Heterogeneity of extracellular vesicles: Isolation and detection strategies. Chem. Eng. J. 507: 160234. (IF=13.3,中科院一区Top)
5.Zhao L-X#, Sun Q#, Wang C, et al., Xu W-H*, Xu R* (2024). Toxoplasma gondii-derived exosomes as tumor immunotherapy platform. Int. J. Nanomed. 19: 12421-12438. (IF=6.6,中科院二区Top)
6.Shen Y-Q#, Sun L#, Wang S-M, et al., Zheng X-Y*, Xu R* (2024). Exosomal integrins in tumor progression and clinical prediction. Int. J. Oncol. 65(6): 118. (IF=4.5,中科院三区)
7.Shao L-M#, Zhang H-R#, Sun L#, et al., Xu R*, Jia F* (2025). Responsive degradable bottlebrush polymers for enhanced drug efficacy. Adv. Healthc. Mater. 14(6): 2405202. (IF=10.0,中科院一区Top)
8.Chen X#, Sun L#, Ning Y-J, et al., Guo Y-C*, Xu R*, Wu J-W* (2025). Injectable polydopamine/curcumin dual-modified coaxial fibers for oral squamous cell carcinoma. Int. J. Biol. Macromol. 292: 139094. (IF=7.7,中科院一区Top)
9.Xiao J-M#, Zhang G-L#, Xu R#, et al., Wu Z-Y*, Zou D-H* (2019). pH-responsive platform combining chemodynamic therapy with limotherapy for cancer theranostics. Biomaterials. 216: 119254. (IF=10.317,中科院一区Top)
10.Liu X-C#, Zhang H-J#, Xu R#, et al., Tian Z-Q*, Yu Z-L*, Chen G* (2024). NIR-II quantum dot-assisted dual-color imaging for simultaneous tracking of two extracellular vesicle subtypes in vivo. Chem. Eng. J. 492: 152242. (IF=13.3,中科院一区Top)
11.Liu J#, Yu Z-L#, Xu R#, et al., Chen G*, Tian Z-Q* (2023). NIR-II quantum dot-based fluorescence anisotropy probes for PD-L1 detection. Sens. Actuators B Chem. 376: 132962. (IF=8.0,中科院一区Top)
联系方式
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