夏伦果

夏伦果，男，安徽医科大学口腔医学院校聘教授，主任医师，博士生导师，中华口腔医学会口腔正畸专业委员会常务委员兼学术秘书，中华口腔医学会口腔美学专业委员会委员，国家口腔医学中心口腔正畸专科联盟理事。入选国家青年高层次人才计划，上海市启明星人才计划和上海市卫健委优秀青年人才计划。2013年于上海交通大学获得博士学位，现任上海交通大学医学院附属第九人民医院口腔正畸科常务副主任。

主要研究方向为牙颌面畸形患者伴颌骨发育不足/缺损的生长/再生正畸相关基础与临床转化研究。主持包括国家自然科学基金、上海市科委启明星人才项目、上海市科委生物医药领域科技支撑项目等多项科研项目。研究成果以第一作者或通讯作者（含共同）发表在ACS Nano、Advanced Science、 International Journal of Oral Science、Biomaterials、Chem Eng J和Adv Healthc Mater等国际权威期刊。

科研项目（在研）：

1. 国家自然科学基金面上项目，SPD-MTP-RORγt轴在氧化应激诱导Treg/Th17免疫失衡导致牙周炎牙槽骨吸收机制及干预研究，2026/1-2029/12，49万元，在研，主持

2. 上海交通大学医学院青年高层次人才匹配经费，2024.01-2026.12，50万元，在研，主持

3. 上海第九人民医院国家级激励计划，2024.01-2029.12，350万元，在研，主持

奖励：

1.2025年上海市科技进步一等奖

2.2019年上海市“启明星”人才

3.2024年上海产学研合作优秀项目奖一等奖《数字化青少年小下颌畸形矫形器的研发及产业化》

4.2022年中华口腔医学会科技奖 三等奖《颌骨生长及再生的正畸技术创新及推广应用》

5.2025年上海市知识产权创新奖三等奖

近五年代表性论文（近五年所有文章）：

(1)Zhu Z#, Li R#, Mei P, Zhu C, Li T, Li Y, Tan W, Yang Y, Jin Y, Guo W, Fang R, Xia L*, Fang B*. Lithium-doped silicon-hydroxyapatite nanowires alleviate early bone loss in periodontitis via γδ T cell modulation. Chemical Engineering Journal. 2025 Jun 20;519:165072. https://doi.org/10.1016/j.cej.2025.165072（IF：13.2，1区Top）

(2)Mei P#, Tao X#, Ding Z, Li R, Zhu Z, Liu C, Wang R, Xia L*, Huan Z*, Fang B*. Multifunctional Lithium-Calcium-Silicon Bioceramic Resin Composite for Enhanced Dental Remineralization and Reparative Dentin Formation. Adv Healthc Mater. 2025 Nov;14(30):e00530. doi: 10.1002/adhm.202500530 . Epub 2025 Aug 5. PMID: 40761021. （IF：9.6，1区）

(3)Li Y#, Li T#, Zhu C, Li H, Fang R, Li R, Jin Y, Zhu Z, Xia L*, Fang B*. Stable‐Dynamic hydrogels mimicking the pericellular matrix for articular cartilage repair. Advanced Healthcare Materials. 2025 Mar 30;14(12):e2405081. https://doi.org/10.1002/adhm.202405081（IF：9.6，1区）

(4)Zhu C#, Huang K#, Li T#, Li Y, Jin Y, Li R, Zhu Z, Yang S*, Xia L*, Fang B*. Manganese dioxide coupled metal-organic framework as mitophagy regulator alleviates periodontitis through SIRT1-FOXO3-BNIP3 signaling axis. Biomaterials. 2025 Aug;319:123179. doi: 10.1016/j.biomaterials.2025.123179. Epub 2025 Feb 8. PMID: 39983516. （IF：12.9，1区Top）

(5)Xia L#, Zhou C#, Mei P, Jin Z, He H, Wang L, Bai Y, Chen L, Li W, Wang J, Hu M, Song J, Cao Y, Liu Y, Hou B, Wei X, Niu L, Lu H, Ma W, Wang P, Zhang G, Guo J, Li Z, Lu H, Ren L, Xu L, Wu X, Lu Y, Hu J, Yue L*, Zhang X*, Fang B*. Expert consensus on the prevention and treatment of enamel demineralization in orthodontic treatment. Int J Oral Sci. 2025 Mar 1;17(1):13. doi: 10.1038/s41368-024-00335-7. PMID: 40021614; PMCID: PMC11871012. （IF：10.8，1区）

(6)Meng L, Shu M, Mei P, Liang Y, Xia L*. Size-controllable synthesis of hydroxyapatite nanorods via fluorine modulation: applications in dental adhesives for enhanced enamel remineralization. BMC Oral Health. 2025;25(1). doi:https://doi.org/10.1186/s12903-025-05574-6（IF：3.1，1区）

(7)Liu C#, Yu B#, Zhang Z#, Su L, Wang R, Jin Y, Guo W, Li R., Zeng Z, Mei P, Chang J, Xia L* Yang C*, & Fang B*. LIPUS activated piezoelectric pPLLA/SrSiO3 composite scaffold promotes osteochondral regeneration through P2RX1 mediated Ca2+ signaling pathway. Biomaterials. 2025;317:123084. doi:https://doi.org/10.1016/j.biomaterials.2025.123084（IF：12.9，1区Top）

(8)Li T#, Shu M#, Zhu C#, Liu Q, Li Y, Wang R, Chen L, Shi W, Sun Z, Hou Z*, Fang B*, Xia L*. Triple-Combination Therapy with a Multifunctional Yolk-Shell Nanozyme Au@CeO2 Loaded with Dimethyl Fumarate for Periodontitis. Adv Sci (Weinh). 2024 Dec 24: e2413891. doi: 10.1002/advs.202413891. （IF：14.3，1区Top）

(9)Li T#, Shu M#, Zhu C#, Li Y, Liu Q, Zhu Z, Jiang Y, Mei P, Jin Y, Fang B*, Xia L*. Au@CeO2 yolk-shell nanozymes restore mitochondrial dynamics and enhance chondrogenic drug response for cartilage regeneration in osteoarthritis. Chemical Engineering Journal. 2024 Jun 15;495:153130. https://doi.org/10.1016/j.cej.2024.153130（IF：13.2，1区Top）

(10)Li R#, Zhu C#, Chu F, Yu Q, Fan D, Ouyang N, Jin Y, Guo W, Xia L*, Feng Q*, Fang B*. Deep learning for virtual orthodontic bracket removal: tool establishment and application. Clin Oral Investig. 2024; 28(1): 121. （IF：3.1，1区）

(11)Yu Jin, Mengmeng Shu, Zhen Liu, Hairui Li, Chengxiao Liu, Cheng Zhu, Zhiyu Zhu, Bing Fang*, Lunguo Xia*. Bio-functional immunomodulatory europium-doped hydroxyapatite nanorods for osteochondral repair via CDH5-RAS-RAF-MEK-ERK-CSF1 axis. Chemical Engineering Journal. 2024; 484: 149311. （IF：13.2，1区Top）

(12)Li R#, Zhu Z#, Zhang B, Jiang T, Zhu C, Mei P, Jin Y, Wang R, Li Y, Guo W, Liu C, Xia L*, Fang B*. Manganese Enhances the Osteogenic Effect of Silicon-Hydroxyapatite Nanowires by Targeting T Lymphocyte Polarization. Adv Sci (Weinh). 2024; 11(4): e2305890. （IF：14.3，1区Top）

(13)Xia L, Wu T, Chen L, Mei P, Liu L, Li R, Shu M, Huan Z, Wu C, Fang B. Silicon-Based Biomaterials Modulate the Adaptive Immune Response of T Lymphocytes to Promote Osteogenesis/Angiogenesis via Epigenetic Regulation. Adv Healthc Mater. 2023 Oct 16: e2302054. （IF：10，1区）

(14)Li H#, Li H#, Yuan L, Liu C, Xiao S, Liu Z, Zhou G, Dong T, Ouyang N, Liu L, Ma C, Feng Y, Zheng Y*, Xia L*, Fang B*. The psc-CVM assessment system: A three-stage type system for CVM assessment based on deep learning. BMC Oral Health. 2023 Aug 12; 23(1): 557. （IF：2.6，1区）

(15)Liu L, Yu F, Chen L, Xia L*, Wu C*, Fang B*. Lithium-Containing Biomaterials Stimulate Cartilage Repair through Bone Marrow Stromal Cells-Derived Exosomal miR-455-3p and Histone H3 Acetylation. Adv Healthc Mater. 2023; 12(11): e2202390. （IF：10，1区）

(16)Li Y, Xiao S, Jin Y, Zhu C, Li R, Zheng Y, Chen R*, Xia L*, Fang B*. Stress and movement trend of lower incisors with different IMPA intruded by clear aligner: a three-dimensional finite element analysis. Prog Orthod. 2023; 24(1): 5. （IF：3.5，1区）

(17)Sun L#, Chen X#, Chen R, Ji Z, Mu H, Liu C, Yu J, Wang J, Xia R, Zhang S, Xu Y*, Ma K*, Xia L*. Balancing the antibacterial and osteogenic effects of double-layer TiO2 nanotubes loaded with silver nanoparticles for the osseointegration of implants. Nanoscale. 2023; 15(6): 2911-2923. （IF：5.8，1区）

(18)Guo W#, Jin P#, Li R, Huang L, Liu Z, Li H, Zhou T*, Fang B*, Xia L*. Dynamic network biomarker identifies cdkn1a-mediated bone mineralization in the triggering phase of osteoporosis. Exp Mol Med. 2023; 55(1): 81-94. （IF：9.5，1区Top）

(19)Jin Y#, Zhang Q#, Qin X#, Liu Z, Li Z, Zhong X*, Xia L*, He J*, Fang B*. Carbon dots derived from folic acid attenuates osteoarthritis by protecting chondrocytes through NF-κB/MAPK pathway and reprogramming macrophages. J Nanobiotechnology. 2022; 20(1): 469. （IF：10.2，1区Top）

(20)Zhu C#, Li R#, Yuan L, Zheng Y, Jin Y, Li H, Liu C, Xia L*, Fang B*. Effects of the advanced mandibular spring on mandibular retrognathia treatment: a three-dimensional finite element study. BMC Oral Health. 2022; 22(1): 271. （IF：2.6，1区）

(21)Zhou Y#, Hu Y#, Uemura M, Xia L*, Yu X*, Xu Y*. Fabrication and Effect of Strontium-Substituted Calcium Silicate/Silk Fibroin on Bone Regeneration In Vitro and In Vivo. Front Bioeng Biotechnol. 2022; 10: 842530. （IF：4.3，1区）

(22)Sun L, Chen X, Mu H, Xu Y, Chen R, Xia R*, Xia L*, Zhang S*. Titanium Nanobowl-Based Nest-Like Nanofiber Structure Prepared at Room Temperature and Pressure Promotes Osseointegration of Beagle Implants. Front Bioeng Biotechnol. 2022; 10: 841591. （IF：4.3，1区）

(23)Yu F#, Lian R#, Liu L#, Liu T, Bi C, Hong K, Zhang S, Ren J, Wang H, Ouyang N, Du LJ, Liu Y, Zhou L, Liu Y, Fang B*, Li Y*, Duan SZ*, Xia L*. Biomimetic Hydroxyapatite Nanorods Promote Bone Regeneration via Accelerating Osteogenesis of BMSCs through T Cell-Derived IL-22. ACS Nano. 2022, 16: 755-770. （IF：17.1，1区Top，自然指数期刊）

(24)Jiang S, Wang X, Ma Y, Zhou Y, Liu L, Yu F, Fang B, Lin K, Xia L*, Cai M*. Synergistic Effect of Micro-Nano-Hybrid Surfaces and Sr Doping on the Osteogenic and Angiogenic Capacity of Hydroxyapatite Bioceramics Scaffolds. Int J Nanomedicine. 2022; 17: 783-797. （IF：6.7，1区）

(25)Li J, Guo W, Yu F, Liu L, Wang X, Li L, Fang B*, Xia L*. Low-intensity pulsed ultrasound promotes angiogenesis via the AKT pathway and DNA methylation in human umbilical vein endothelial cells. Ultrasonics. 2022: 106561. （IF：1.3，1区）

(26)Cui J#, Xia L#, Lin K, Wang X. In situ construction of a nano-structured akermanite coating for promoting bone formation and osseointegration of Ti-6Al-4V implants in a rabbit osteoporosis model. J Mater Chem B. 2021; 9(46): 9505-9513. （IF：6.1，1区）

(27)Jin Y#, Li Z#, Wu Y, Li H, Liu Z, Liu L, Ouyang N, Zhou T, Fang B*, Xia L*. Aberrant Fluid Shear Stress Contributes to Articular Cartilage Pathogenesis via Epigenetic Regulation of ZBTB20 by H3K4me3. J Inflamm Res. 2021; 14: 6067-6083. （IF：4.2，2区）

(28)Wang X#, Guo W#, Li L, Yu F, Li J, Liu L, Fang B*, Xia L*. Photothermally Triggered Biomimetic Drug Delivery of Teriparatide via Reduced Graphene Oxide-Loaded Chitosan Hydrogel for Osteoporotic Bone Regeneration. Chemical Engineering Journal. 2021; 413: 127413. （IF：16.74，1区Top）

(29)Liu L, Yu F, Li L, Zhou L, Zhou T, Xu Y, Lin K*, Fang B*, Xia L*. Bone marrow stromal cells stimulated by strontium-substituted calcium silicate ceramics: release of exosomal miR-146a regulates osteogenesis and angiogenesis. Acta Biomater. 2021; 119: 444-457. （IF：9.4，1区Top）

联系方式：

E-mail：xavierxlg@126.com；lunguoxia2026@ahmu.edu.cn

地址：安徽省合肥市安徽医科大学口腔医学院